Chronic urothelial inflammation associated with UTI in women: A Clinicopathological study

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Chronic urothelial inflammation associated with UTI in women: A Clinicopathological study

Author(s) : Laraib Ali, Iram Yousaf, Hikmat Yar Khan, Rameez Ahmed Mughal, Rao Nouman Ali & Niamatullah

Abstract:
DOI: https://doi.org/10.52587/njhms.v5i2.67

Abstract
Objective:
Chronic urothelial inflammation associated with urinary tract infections (UTIs) in women presents a significant clinical challenge, often leading to recurrent episodes and potential complications. The main objective of this study was to find the clinicopathological correlation of chronic urothelial inflammation associated with UTI in women.
Material and Methods:
This cross-sectional study was conducted in Urology Department, Shifa International Hospital Islamabad from 2022-2023. Data were collected from 220 female patients suffering from UTI. Data were collected from 220 female patients according to inclusion and exclusion criteria. All the demographic and clinical data were noted on systematically designed questionnaire. Medical history, clinical symptoms and imaging findings were also extracted from hospital record.
Results:
Data were collected from 220 female patients. Mean age was 45.6 ± 10.2 years and mean BMI was 26.8 ± 3.5kg/m2. Hypertension was the most prevalent comorbidity at 35%, followed by diabetes mellitus at 20% and chronic kidney disease at 10%. Recurrent UTIs were reported by 60% of participants, while 40% experienced their first-time UTI. The treatment outcomes were predominantly favorable, with 90% of patients showing a positive response. Symptoms resolved within 7-10 days for most cases, indicating an effective therapeutic intervention. However, 10% of patients required hospitalization, suggesting the severity of their condition or the need for more intensive management strategies.
Conclusion:
Chronic urothelial inflammation is prevalent among women with urinary tract infections (UTIs), characterized by lymphocytic infiltrate and a microbiological profile dominated by Escherichia coli.

Keywords: UTI, Women, Infection, Inflammation, Therapeutics