HOMA-IR based Insulin Sensitivity Index in Normal Pregnancy in Lahore-Pakistan

Author(s) : Shazia Ramzan, Zara Mehboob, Zobiah Hafeez, Nooria Naeem, Zaheer Iqbal Sheikh & Manzoor Ahmad

Abstract:

DOI:https://doi.org/10.52587/njmhs.v4i2.43

Objective:
This study is carried out to assess the adapted insulin mechanism through comparative insensitivity in early pregnancy in the population of Lahore region.
Material and Methods:
Sixty-five subjects in early pregnancy stage and twenty-five non-pregnant subjects volunteered for the present study. General data and blood samples of all the participants were obtained. Glucose and insulin level in the blood were assayed and analyzed statistically.
Results:
It was found that insulinemia was 67 more in pregnant females when compared to non-pregnant controls, with significant difference in the comparing groups (p<0.0001). Comparative study found hyperinsulinemia in the phases of the pregnancy. Glycemia was found to be 5.4% lesser in pregnant females as compared to the non-pregnant controls. Thus there was a non significant difference in values in both the comparing groups. The relationship based on HOMA-IR concept was also analyzed and the value observed was 6.700.37 in the control non-pregnant subjects of the study. In early pregnancy subjects the values were 10.880.39. The relationship shows about 62% greater insulin index in the pregnant subjects as compared to the non-pregnant controls. The difference is highly significantly different statistically (p=0.0007).
Conclusion:
The responses of the insulin to the glycemia acquired in the early pregnancy certainly showed comparative insulin insensitivity in early pregnant subjects as compared to the non-pregnant controls. The pattern of insulin insensitivity in the early pregnancy in a subject may also provide clue of the development of gestational diabetes at the later stage of the gestation.

Keywords: Glycemia, Insulinemia, Pregnancy, HOMA-IR, Gestational diabetes.