Preventive role of Citric Acid against Acute Myocardial Infarction in rabbits
Author(s) : Hafiz Muhammad Imran Aziz, Farooq Sultan, Binish Anwar, Obaid Anwar, Sobia Zahur Malik & Aftab Nazir
The study was planned to measure markers of myocardial injury in experimental model of acute myocardial infarction.
Material and Methods:
This was a randomized experimental study. In the study, 40 male rabbits were included and distributed equally into five groups. During first 14 days, G-1 and G-2 (control group and Iso-control group) animals got 1ml normal saline, while G-3, G-4 and G-5 animals got citric acid at the dose of 250 mg/kg, 500 mg/kg and 750 mg/kg body weight respectively. Isoproterenol (85mg/kg body weight) was injected subcutaneously for induction of acute myocardial infarction in experimental model except for G-1. Markers of myocardial injury like serum- CK-MB, LDH., SGOT and SGPT were analyzed in the study.
The data in the study shows that there was significant rise in myocardial injury markers such as CK-MB, LDH, SGOT and SGPT as compared to control-group indicating severe infarction and myocardial cell death. On the other hand, citric acid treated groups showed significant restoration of CK-MB, LDH, SGOT and SGPT as compared to Iso-control group.
It is clear from this study that citric acid possesses cardio protective potential. It reduces the impact of ischemic injury to myocardium during acute attack of myocardial infarction, evident by reduced cardiac enzymes levels.
Keywords: Acute myocardial infarction, Cardio protection, Isoproterenol, Cardiac Enzymes, CK-MB, LDH, Citric acid.