Biochemical and Hematological assessment of Tuberculosis patients on Anti-tuberculous drugs in Quetta-Balochistan

Author(s) : Wazeer Muhammad, Mohammad Alam Mengal, Irfan shazad Sheikh, Rehan Ahmed, Saleem Haider, Syed Haseeb Shah, Akthar Mengal, Jhanzaib & Muhammad Zahid Mustafa

Abstract:

DOI: https://doi.org/10.52587/njmhs.v4i1.15

Objective:
Tuberculosis affects mainly lungs, and other organs of human body such as brain, bones and intestine may be involved. Tuberculosis treatment causes significant hematological and biochemical changes during treatment. The aim of this study was to assess the hematological profile of TB patients who are treated with anti-TB drugs.

Material and Methods:
This descriptive study was carried out on newly diagnosed pulmonary TB patients who were treated with standard regimen for the treatment of TB. The data before the treatment and during the treatment of five-month was collected at FJC Hospital, Quetta-Pakistan. The data about the indicator enzymes of hepatocellular functions in the serum (such as ALT, AST and ALK-P) and the hematological parameters (such as changes in RBC and WBC counts) during tuberculosis treatment were included in the study.
Results:
The level of different biochemical and hematological parameters in the blood were significantly affected. The mean value of RBC count in TB patient before treatment was 4.89±0.51 million cells/mcL and after five-month treatment it was 4.84±0.54 million cells/ mcL. The average total WBC in TB patients before treatment (10.29±1.49 ×109/L) and after completion of five-month treatment (6.83±.97×109/L) decreases significantly. The mean thrombocyte count in TB patients before treatment (244.98±20.32×109/L) and after five-month treatment (244.66±28.37×109/L) changed slightly. The ALK-P in TB patient before treatment was 111.10±12.9 IU and after completion of five-month of anti TB drugs the value was 127.80±7.2 IU, which slightly increased. The mean ALT in TB patient before treatment was 39.56±1.37U/L and after five-month treatment it was 43.56±4.16U/L. The average globulin level in TB patient after completion of five-month treatment increased significantly.
Conclusion:
The data showed significant variations in the different biochemical and hematological parameters in the blood of TB patients before initiation and after the completion of anti-TB treatment. The TB patient should be monitored during and after intensive phase of treatment especially for liver enzymes.

Keywords: Biochemical assessment, anti TB drugs. Liver enzyme, Hematological indices