Biochemical and Hematological assessment of Tuberculosis patients using Anti-tuberculous drugs in Quetta Balochistan

Author(s) : Wazeer Muhammad, Mohammad Alam Mengal, Irfan shazad Sheikh, Rehan Ahmed, Saleem Haider, Syed Haseeb Shah, Akthar Mengal and Jhanzaib

Abstract:

DOI: https://doi.org/10.52587/njmhs.v4i1.15

Objective:
Tuberculosis mainly affects lunges and other organs of human body such as brain bones and intestine may be involved. Tuberculosis treatment causes significant hematological and biochemical changes during treatment.
Material and Methods:
Positive new TB patient which was enrolled in treatment are selected. This descriptive study was carried out on pulmonary TB patients who were treated with standard regimen before treatment and during treatment five-month data was collected at FJCH Quetta Baluchistan. Indicator of hepatocellular function enzyme included ALT, AST, changes have been observed almost in all patients. The Hematological changes Include drug induced aplastic Anemia, changes in RBC and WBC counts have been observed with tuberculosis treatment.
Results:
The level of blood continent is significantly affected. The mean among RBC count in TB patient before treatment (4.89±51) and after five-month treatment it was (4.84±54) and it was slightly lower. The average total no of WBC of TB patient before treatment (7.29±.19) after completion of five-month treatment it was (7.21±15.2) slightly increases in number. The mean among thrombocyte count in TB patient before treatment was (244.98±) and after five-month treatment it was (244±28) and it was slightly lower in number. The total ALK-P of TB patient using anti TB drugs before treatment (111.10 ±12.9) and after completion of five-month treatment (127.80±7.2) it was slightly increases. The mean among ALT in TB patient before treatment (39.56±1.37) and after five-month treatment it was (43.56±4.16) and it was slightly higher. The average Globulin level in TB patient before treatment was (3.50±.45) and after completion of five-month treatment (5.03±63) it was slightly increases.
Conclusion:
The level of blood chemistry is significantly lowered after completion of five-month treatment. It shows significant variation before initiation and after completion hematological abnormalities in TB patient should be checked during tuberculosis treatment. LFT including ALKP and ALT biomarkers are slightly increases. And should be monitored during and after intensive phase of treatment.

Keywords: Biochemical assessment, anti TB drugs. Liver enzyme, Hematological indices