Comparison of the treatment response of Azithromycin and Ciprofloxacin against Salmonella Typhi infection in children

Author(s) : Hafiz Muhammad Imran Aziz, Amna Asghar, Binish Anwar, Aftab Nazir, Sobia Zahur Malik and Ata Ur Rehman

Abstract:

DOI: https://doi.org/10.52587/njmhs.v4i1.32
Objective:
This study aims to compare the compare the treatment response of azithromycin against ciprofloxacin while treating salmonella infection in children.
Material and Methods:
The study was conducted in Yaseen Memorial Hospital, Faisalabad Pakistan. Informed written consent was taken from parents or guardians of patients. The sample size of the study was 200 children. The Patients that are included in the study after fulfillment of the criteria were included in study and were randomly divided into Azithro-group and Cipro-group. Cipro-group was treated with oral ciprofloxacin 15mg/kg/dose twice a day for 7 days. Azithro-group was treated with oral azithromycin 10mg/kg/dose Once/day for 7 days. Patients were closely monitored during the whole study period.
Results:
Out of 200 patients, 125 patients fall between 3- to 8-year age group. Out of these, 71 were in Cipro-group and 54 were in Azithro-group. Rest of the 75 patients fall between the 9- to 14-year age group. Out of these, 29 were in Cipro-group whereas 46 in Azithro-group. The Comparative efficacy of the oral azithromycin vs oral ciprofloxacin in children with typhoid infection demonstrates that 89% patient in Azithro-group and 68% patient in Cipro-group met the criteria of effectiveness. While 32% in Cipro-group and 11% in Azithro group did not meet the criteria of effectiveness despite the same treatment. Differences were considered statistically significant if p<0.05.
Conclusion:
Clinical treatment response with azithromycin is significantly higher both age groups of children in comparison to ciprofloxacin for treating typhoid fever.

Keywords: Children, Typhoid fever, treatment response, azithromycin, ciprofloxacin