Protective effect of strain specific probiotic formulation (Renadyl) following Gentamicin induced nephrotoxicity in albino rats

Author(s) : Rabia Akram, Sadia Khalil, Javeria Maqbool, Arslan Iftikhar, Arslan Shaukat, Tehreem Iman, Faiqa Sajid, Nayab, Nimra Iqbal, Haseeb Anwar

Abstract:

Objective:
This Experimental study was organized to investigate the ameliorating effect of Renadyl on some hematological and biochemical changes in young male rats after gentamicin induced nephrotoxicity.
Material and Methods:
Total eighteen (18) rats were used and divided into a control group (n=6) and treated groups (n=12). Gentamicin was given through the intraperitoneal route for 8 days. After 8 days half (n=6) rats were sacrificed from the treated group. Renadyl was administered orally to the remaining rats (n=6) for a further 10 days. After this rats were decapitated for investigation.
Results:
Data were analyzed by one way ANOVA. A significant difference (p≤0.05) was found in mean corpuscular hemoglobin, creatinine, urea, HDL, LDL, glucose, TAC, TOS, kidney, and liver weight in Renadyl treated group as compared to Gentamicin treated group. The results indicated that Renadyl has the potential to reduce toxicity level induced by gentamicin by using creatinine and other toxic agents as their food ingredients and also remove enteric toxins which further provoke kidney damage.
Conclusion:
Renadyl possesses a nephroprotective approach against Gentamicin induced nephrotoxicity.

Key Words: Gentamicin, Nephrotoxicity, Renadyl, nephroprotective