Association of Lung Cancer with Tobacco smoking; a review

Author(s) : Mahnoor Fatima, Naveed Munir, Zahed Mahmood, Muhammad Jahangir

Abstract:

Smoking is leading cause of lung cancer accounting for about 85% lung cancer cases. Even, illness associated with smoking caused about 5 million deaths globally every year. It is alarming that about one-third of adults globally are considered to be smokers and this rate is significantly increasing in female. It is worrisome that estimated deaths attributed to tobacco smoking will rise up to 10 million by 2025. A number of researches reported strong association between cigarettes smoking and lung cancer and cigarette smoking related deaths accounts about one-third of all adult deaths. A constant smoker has 20-40 times higher risk for the development of lung cancer as compared to non-smokers. About sixty carcinogens have been identified in cigarette in laboratory settings which are proven to induce carcinoma. This review article described the linkage of lung cancer and smoking with some etiologies for the development of cancer in tobacco consumers.

Key Words: Smoking, DNA adducts, carcinogenic metabolites, pulmonary cancer