Dyslipidemias in the patients with end-stage renal disease on conventional hemodialysis in three months follow-up

Author(s) : Nighat Fatima, Saifullah Goraya & Sheraz Saleem

Abstract:

Objective:
The objective of study was to determine the pattern of dyslipidemias in patients with end-stage renal disease on conventional hemodialysis in three months duration.
Material and Methods:
This study was conducted in the Department of Medicine and Dialysis Unit, Sargodha Medical College, District Headquarter Teaching Hospital, Sargodha. We conducted conventional hemodialysis (2cycles/week) for at least three hours and measured fasting lipid profile of 115 subjects with end-stage renal disease.
Results:
Our study included 115 subjects with end-stage renal disease. The mean age was 51.03 ±10.73 years. Out of 115 subjects, 69 (60%) were male and 46 (40%) were female. From study population, 39 (33.9%) patients were smokers and 76 (66.1%) patients were non-smokers. The mean baseline HDL cholesterol was 45.19±4.9 mg/dl, which after the end of study period was 41.07±8.57mg/dl. The difference was statistically significant as indicated by the p-value <0.001. The mean baseline triglyceride was significantly increased before and after the study. Almost all of our sample population exhibited elevated serum triglycerides and decreased HDL.
Conclusion:
The current study findings strongly support the notion that dyslipidemias are more prevalent in patients with end-stage renal disease. It could be an independent causative factor for cardiovascular deaths in end-stage renal disease. Additional large-scale case-control studies are needed to further strengthen the above statement.

Key Words: End-Stage Renal Disease, Lipid Profile, Conventional Hemodialysis